maxxiSAMe Liver and Cognitive Support for Dogs

Proven support for liver and cognitive functions while easing joint discomfort

SAM-e synthesis is a naturally occurring reaction within the livers and brains of dogs. While in the liver, it aids in the critical function of cleaning out the build-up of unwanted waste and may help repair cell damage. In the brain, SAM-e helps increase dopamine function, stimulates healthy cognitive function and works as an antioxidant.

Additionally, researchers have identified SAM-e as an effective anti-inflammatory that improves joint health. This means that pets that are already on maxxiSAMe, receive valuable joint support for minor everyday discomfort. However, if your dog has pre-existing joint problems and/or arthritis, they will still benefit from an additional joint supplement like maxxiflex+.

maxxiSAMe not just SAM-e but advanced SAM-e formula for dogs

Happy fun scruffy dog using maxxiSAMe SAM-e for dogs

Patented stabilized powder works efficiently for the health of your dog

Our SAM-e formulation is specifically designed to protect the vulnerable SAMe nutrient from decreasing in potency.

Our fiber base protects against the acidity levels in dog’s stomach and allows for quick absorption into the intestinal track.

Our base also contains defatted flax, sunflower, and sesame seed fiber with naturally occurring immune and hormone boosting functions.

In addition to the intestinal support provided by the fiber, there are also the antioxidants provided by lignans, a group of chemical compounds found in plants that support immune systems and may help regulate hormone levels.

Boosted with additional valuable antioxidants and vitamins

We carefully formulated maxxiSAMe to provide serious support for ill or aging pets.

There are predictable deficiencies in nutrients that can further impact the overall health of the dog. Not only do our supporting ingredients in maxxiSAMe target liver health and cognitive function, but they also work throughout the body to prime it for the efficient processing of SAM-e.

maxxiSAMe has no artificial flavors, colors, preservatives, or binders.

To learn more about these hardworking supporting ingredients, including artichoke, B vitamins and lignans, and how they help your dog, go to the ingredients section below.

SAM-e as liver supplement for dogs

Learning the health of the dog you love is ailing is difficult. Liver issues often take a noticeable tole on the overall health and behavior of your pet.

Whether your dog is suffering from a chronic liver disease, a breed-specific liver ailment, or toxicities developed from the long-term use of non-steroidal anti-inflammatories (NSAIDS) or acetaminophen (Tylenol). maxxiSAMe can serve as an effective part of the care plan developed by your veterinarian.

S-adenosylmethionine (SAM-e), one of the active ingredients in maxxiSAMe, is proven to help prevent the build-up of unwanted materials in the liver so it functions efficiently. SAM-e supplementation helps protects the liver from further damage and may also help with cell repair.

SAM-e as cognitive support for dogs

As pets age, they too can be impacted by cognitive degeneration.

Cognitive Dysfunction Syndrome (CDS) is the result of age-related changes in the brain and can appear as confusion, memory loss and other symptoms of reduced mental function.

Unfortunately, cognitive dysfunction is incurable but early diagnosis and intervention can slow it down and improve your dogs' quality of life.

Working as an antioxidant, SAM-e helps increase dopamine function in the brain and is a safe and effective way to stall mental decline in aging pets.

Supports your dog where and when they need it most

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Advanced brain, joint and liver supplement for dogs

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maxxiSAMe SAM-e for dogs given with food

Designed to be given easily with food

Our maxxiSAMe powder is designed to be mixed right in to your dog's food as part of their regular meals.

Other formulations of SAM-e for dogs may require a pill or chewable to be given one full hour before a meal on an empty stomach. No dog, or dog owner, enjoys that.

And our patented base containing additional vitamins and antioxidants, decreases the need for additional supplements related to your dog’s cognitive or liver health issues.

Easy to follow dosage instructions for dogs of any size

With maxxiSAMe just sprinkle the daily dosage over two meals a day, allowing for the maximum absorption of all ingredients.

Our powder formulation allows you to give the exact amount needed, making it easy to increase or decrease at the recommendation of your veterinarian.

Coated tablets containing SAM-e are sensitive to moisture and heat, and therefore cannot be split or crumbled without loosing the efficacy.

SAM-e is hard at work behind the scenes

While SAM-e is hard at work within your beloved pet’s liver and brain, expect marked improvements in attitude, energy, and the behavior of your dog.

What Our Customers Say

maxxiSAMe advanced SAM-e formula for dogs

Logo maxxiSAMe advanced SAM-e formula for dogs

Supports your dog where and when they need it most

As pets grow older, they can face many of the same age-related health conditions as humans. Our unique stabilized SAM-e powder boosts liver and cognitive functions while easing joint discomfort and improves mood at the same time. While maxxiSAMe is hard at work within your beloved pet’s liver and brain, expect marked improvements in attitude, energy, and the behavior of your dog.


  • Proven support for liver and cognitive functions while easing joint discomfort
  • Boosted with additional valuable antioxidants and vitamins
  • Easy administration, can be given with food

Frequently Ask Questions

about maxxiSAMe liver and cognitive support for dogs

We always recommend starting slowly with any new supplement and gradually increase the amount given. This allows your dog to get used to the new ingredients, both the taste and texture, and helps to minimize the risk of any potential stomach upset.

The recommended maintenance dosage is shown on the back of the label. If you are using maxxiSAMe to treat a specific health condition, then you may want to increase the dosage while getting the condition under control. The recommended saturation dosage is double the maintenance amount.

You can reduce the dosage to maintenance dosage once the condition has improved. This is one of the many benefits of powder formulation. It is easy to adjust the dosage in line with your dogs need over time. 

One scoop (included) is 2.5 gram and equates to 1 teaspoon (baking measure teaspoon). 

It is recommended dividing the daily dosage between two servings as this maximizes the absorption of all the ingredients.

If you only feed your dog once a day, then you may want to introduce daily treat time with maxxiSAMe for the second serving, e.g. by making pate ball filled with maxxiSAMe.

Yes you can give maxxiSAMe with food.

This is because the SAM-e used in maxxiSAMe is a patented stabilized powdered form of SAM-e. This protects the SAM-e from interaction with environmental factors, as well as from the other ingredients used in the formulation.

This also protects the SAM-e in the stomach and ensures it makes it to the intestine where it is absorbed, i.e. it guarantees the availability of the active substance (SAM-e) when taken orally.

This is also why maxxiSAMe can be given with food, unlike coated SAM-e pills which must be taken on an empty stomach an hour before or after mealtimes.

As maxxiSAMe is powder you need to administer the dosage amount yourself and you may be concerned about getting the dosage exactly right. Especially those with small dogs as some may find it tricky to measure smaller amounts.

You don't need to be overly concerned about this. SAM-e is a natural ingredient that is safe in higher dosages than we recommend. If you give your dog maxxiSAMe twice a day as recommended, then a little bit more or less per serving will ensure you meet the daily requirements over time.

The easiest way to administer maxxiSAMe is to mix it in with your dog's food. maxxiSAMe has a natural flavour as it does not contain any artificial flavours, colours, preservatives, or binders. The vast majority of dogs happily eat their food when maxxiSAMe has been added to it.

Others may prefer daily SAM-e treat. There are a number of ways of doing this. By adding a small amount of water, you can make a "paste". Some dogs happily accept it just like that. For others it works better to mix it with something the dog enjoys, like peanut butter, pate or a small piece of chicken or ham. Or you can make a small "ball" (like dry kibble) and put it in his food bowl and put some liquid omega oil on top (as most dogs love the taste of fatty acids).

If your dog is not accepting maxxiSAMe for some reason, please contact us directly and we will offer you some additional tips and support. If we cannot together get your dog to happily accepts his new supplement we will fully refund you.

Because no matter how effective maxxiSAMe is, it will not work if the dog is not taking it. Fortunetly, when we have had the opportunity to work with the owners we have in most cases been successful in getting the dogs to accept their supplements. Which is exactly what we both want. For your dog to feel better with the help of our products.

Store your maxxiSAMe in a cool, dry place. We recommend refrigerating the container after opening.

The best by date is printed on the side of the container.

Yes, maxxiSAMe contains only NON-GMO human grade ingredients that are tested for potency and purity. maxxiSAMe also does not contain any artificial flavours, colours, preservatives or binders.

We do not accept any manufacturing batch unless it conforms to all product specifications.

A Certificate of Analysis is a document issued by Quality Assurance which confirms that the product meets its product specification. It contains the actual results obtained from testing performed as part of quality control of an individual batch of a product.

If you like to see the Certificate of Analysis for your production batch of maxxiSAMe just e-mail us the LOT number (at the bottom of your container) and we will e-mail you a copy.

maxxiSAMe liver and cognitive support for dogs is made in the USA in GMP and NASC (National Animal Supplement Council) certified manufacturing facility. maxxiomega contains only premium grade ingredients, tested for freshness, purity, and potency.

maxxiSAMe is available for both dogs and cats. It is exactly the same product; it is just the label and the size of the container and the scoop that are different. The larger size is maxxiSAMe for dogs and contains 150 g (5.3 oz). While the smaller size is maxxiSAMe for cats and contains 90 g (3.2 oz).

However, there is no reason why cat owners cannot buy the larger container for their cat, or cats. While owners of small dogs may prefer to buy the cat version for the little friend.

maxxiSAMe liver and cognitive support for dogs and cats

Advanced liver and cognitive support for dogs

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maxxiSAMe for dogs is formulated for results





The benefits of maxxiSAMe SAM-e supplement for dogs




Supports your dog where and when they need it most

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